Abstract
A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5-HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Carrier Proteins / metabolism*
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Dopamine / metabolism
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Dopamine Plasma Membrane Transport Proteins
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In Vitro Techniques
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins*
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Nerve Tissue Proteins*
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Serotonin / metabolism
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Serotonin Plasma Membrane Transport Proteins
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Synaptosomes / drug effects
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Synaptosomes / metabolism
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Tropanes / chemistry
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Tropanes / metabolism*
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Tropanes / pharmacology
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Serotonin Plasma Membrane Transport Proteins
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Tropanes
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Serotonin
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Dopamine